Awarded in 2019
Home Department: Genetics, Medicine
Faculty Advisors: Maria Barna (Genetics) and Jonathan Pritchard (Biology and Genetics)

Research Title: Regulation of Gene Translation by Alternative Ribosomal Protein Isoforms in Mammals

Research Description: Alternative ribosomal proteins (aRPs) are a class of largely unexplored genes with the potential to modulate the cellular machinery that mediates expression of every protein-coding gene. Adele proposes a multidisciplinary approach to functionally characterize mammalian aRPs by focusing on a particular aRP both in vitro and in vivo to understand aRPs’ physiological roles, and also to identify other potentially active aRPs genome-wide by developing a high-throughput computational and proteomic pipeline. These approaches will afford unprecedented depth and breadth of knowledge on these enigmatic genes’ physiologic roles in translational regulation.

WHERE IS SHE NOW?

Adele is a resident physician in the Stanford Internal Medicine residency program.